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Cenforce works by blocking the enzyme PDE5, which is responsible for breaking down a compound called cGMP. cGMP plays a key role in regulating blood flow in the penis during sexual arousal. PDE5 usually breaks down cGMP, causing the blood vessels in the penis to constrict. By inhibiting this enzyme, Cenforce pills helps to maintain higher levels of cGMP, which allows the blood vessels to relax and dilate. By blocking PDE5 and enhancing the effects of cGMP, Cenforce helps to relax the smooth muscles in the blood vessels of the penis, allowing more blood to flow into the penis when sexually aroused.